Common name: Polymethoxylated flavones (PMFs)
Synonyms: Polymethoxylated flavonoids(PMFs), Citrus Polymethoxylated flavones (PMFs), Citrus Polymethoxylated flavonoids, PMFs
Active ingredients: Polymethoxylated flavones (PMFs)
The main and key polymethoxylated flavones (PMFs) exist in citrus are Nobiletin, Tangeretin and Sinensetin. Please see below:
Nobiletin
CAS NO.: 478-01-3
Molecular Formula: C21-H22-O8
Molecular Weight: 402.397
Structure:

Tangeretin
CAS NO.: 481-53-8
Molecular Formula: C20-H20-O7
Molecular Weight: 372.371
Structure:

Sinensetin
CAS NO.: 2306-27-6
Molecular Formula: C20-H20-O7
Molecular Weight: 372.371
Structure:

Main Specifications: 8%, 10%, 30%, 40%, 60% , 80%, 90%
Test method: HPLC
Please see the typical HPLC of 60% Polymethoxylated flavones (PMFs) as follow:

Resource: Extract from the Citrus fruits, orange peel
Appearance: Brown fine powder to off-white fine powder
Heavy Metals: NMT10ppm
Residue on Ignition: NMT3%
Residual solvent: Conform to USP39, EP8.0
Packing: 25KG/ cardboard drum
Storage: Store in cool and dry place and keep away from strong direct light and heat
Shelf Life: Two years when properly stored

Applications:

What’s Polymethoxylated flavones (PMFs)?

PMFs are a group of methoxylated phenolic compounds found in tissues and peels of Citrus reticulata (tangerine), Citrus paradisi (grapefruit), Citrus sinensis (sweet orange), and Citrus aurantium L. (sour orange) The main polymethoxylated flavones (PMFs) exist in citrus are Tangeretin, Nobiletin and Sinensetin.

Health Benefits of Polymethoxylated flavones (PMFs)

Methoxylated flavones are natural antioxidants and might reduce inflammation(swelling). They might also affect the way the liver processes cholesterol and other blood fats. Scientists think methoxylated flavones might also reduce the spread of cancer cells.

1.Improves heart health

Polymethoxylated flavones (PMFs) are found to exert positive effect on the heart. These compounds lower your risk of heart disease and inflammation in addition to lowering the blood cholesterol levels (LDL – Low Density Lipoprotein) in the body. Studies have indicated that Polymethoxylated flavones (PMFs) has cholesterol lowering properties. One such found that rats fed with a diet containing Polymethoxylated flavones (PMFs) showed a significantly reduced (up to 40%) serum levels of LDL cholesterol.

2.Anti-caner:

Researchers from Japan’s NARO Western Region Agricultural Research Center found that PMFs inhibits the growth of leukemia by modulating the natural killer cell function. This was accomplished through the biochemical modulating the genetic processes of these natural killer cells. Another, more recent study found that PMFs inhibits the growth of lung cancer cells through a process called notch signaling. Researchers from West Virginia’s Alderson Broaddus University found that PMFs isolated from citrus peels inhibited the growth of two types of prostate cancers. This was accomplished through another complex genetic modulation, including the blocking of VEGF.

3.Liver health

Recently researchers from Japan’s College of Life Sciences in Kusatsu produced PMFs from the peels of the orange fruit. They then tested liver cells in a laboratory and found using chromatography that the PMFs stimulated a healing process among the cells by limiting the produced nitric oxide and stimulated a genetic change (blocking iNOS) that produced a healing effect. The researchers concluded from this finding that PMFs has a healing effect upon the liver.

The Information had not been evaluated by the Food and Drug Administration.