Common name: Nobiletin
CAS NO.: 478-01-3
Molecular Formula: C21-H22-O8
Molecular Weight: 402.397
Specification: From 15% to 98%
Test method: HPLC
Please see the typical HPLC of 98% Nobiletin as follow:
Resource: Extract from the Citrus fruits, orange peel.
Packing: 25KG/ cardboard drum
Storage: Store in cool and dry place and keep away from strong direct light and heat
Shelf Life: Two years when properly stored
What is Nobiletin?
Nobiletin is a typical and key citrus flavonoids. It has the typical flavonoid structure and contains 6 methoxyl groups, one more than tangeretin. This high level of methoxylation increases the hydrophobic character of tangeretin. Pure nobiletin has the appearance of colorless needles and has a bitter taste.
Health Benefits of Nobiletin
Nobiletin seems to be a very noble phytochemical with many potential health benefits. The most studied properties of nobiletin are its anti-inflammatory and anti-cancer activities. Nobiletin also helps to lower cholesterol levels and some studies indicate that it may improve impaired memory loss and treat acne.
1. Cholesterol lowering
A study with cultured macrophages demonstrated the cholesterol lowering and atherosclerosis inhibiting properties of Nobiletin. Nobiletin also inhibits the formation of macrophage foam cells, macrophages loaded wit lipids, which build up on artery walls.
Numerous in-vivo and in-vitro studies have demonstrated the anti-inflammatory activity of Nobiletin and its metabolites. Nobiletin acts directly as an antioxidant but also interferes with biological inflammatory processes. It inhibits the expression of genes involved in inflammation by blocking the binding of NF-kappaB with DNA. One study showed that Nobiletin reduced airway inflammation of asthmatic rats. Treatment of skin cells with Nobiletin also reduced inflammation caused by ultraviolet-B radiation.
The anti-cancer properties of Nobiletin are supported by many scientific studies. Nobiletin act by its antiproliferation effect without being toxic to normal cells. Favorable results have been obtained on cancer cell lines of the liver, stomach, prostate and colon.
4. Memory loss
One study on a mice model showed that Nobiletin may help to improve memory loss. The brains of the mice were chirurgically altered to obtain models of Alzheimer disease. It is not known if Nobiletin improves the condition of human Alzheimer patients.
5. Acne treatment
We found one study showing that Nobiletin inhibited sebum production on hamsters and inhibited the proliferation of sebocytes, the cells that form the sebaceous gland. This observation led the researchers to conclude that Nobiletin could be used as a drug for acne treatment.