Common name: Baicalein
Synonyms: Baicalein; 5,6,7-Trihydroxyflavone
CAS NO.: 491-67-8
Molecular Formula: C15H10O5
Molecular Weight: 270.2369
Specification: 95%, 98%, 99%
Test method: HPLC
Please see the typical HPLC of 98% Baicalein as follow:
Resource: Extract from Scutellaria baicalensis
Used part: Root
Appearance: Light yellow powder
Sulphated Ash <1.0%
Loss on drying <3.0%
Total heavy metals: <10ppm
Total plate count <1000cfu/g
Storage: Store in cool and dry place and keep away from strong direct light and heat
Shelf Life: Two years when properly stored.
What is Baicalein?
Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also reported in Oroxylum indicum or Indian trumpetflower. It is the aglycone of baicalin.
Health Benefits of Baicalein
Neuroprotective properties of Baicalein
Baicalein, as a powerful antioxidant agent has exerted very positive effects against oxidative stress, acting as a free radical scavenger protecting neurons from oxidative stress damage caused by these free radicals. The neuroprotective effect of baicalein, anti-apoptotic, pro-differentiation and its anti-inflammatory mechanism have showed to be another potential way to prevent or treat neurodegenerative diseases as Parkinson's disease.
Baicalein, together with baicalin, wogonin, paeonol, paeonoside, and paeoniflorin have been studied for their neuroprotectant, antioxidant, anti-inflammatory, antithrombotic exerted effects, something that has been demonstrated to have a potential to alleviate the symptoms of neurodegenerative diseases, as Alzheimer's disease and Parkinson's disease.
Baicalein and hepatocellular carcinoma
In studies of the effect of Baicalein in hepatocellular carcinoma, the most common of liver cancers, the combination of baicalein and silymarin were able to eradicate tumor cells.
Baicalein and age-related macular degeneration
Macular degeneration, an ailment affecting mostly elderly people, causes the loss of central vision in those affected by the sickness. Baicalein was also studied as a potential antioxidant agent against age-related macular degeneration , caused by an aging-associated cumulative oxidative stress of the human retinal pigment epithelium.
Baicalein and Baicalin combined action against Breast cancer cells
In spite several studies on the effect of Scutellaria baicalensis extract on Human breast cancer cells didn't achieve the results expected, a study on the effects of its flavonol extracted active constituent, Baicalein, showed certain anti-breast cancer properties using MCF-7 cells.
The combination of baicalein and baicalein was in that study related to apoptosis. Baicalein and wogonin showed significant anti-proliferative effect, inhibiting MCF-7 cell growth, however, in certain concentrations, the same study showed that scutellarin and baicalein increased cancer cell growth.