Common name: Securinine
Synonyms: Securinin; Securinan-11-one; NSC 107413; L-Securinine; (-)-Securinine
CAS NO.: 5610-40-2
Molecular Formula: C13H15NO2
Molecular Weight: 217.26
Specification: 10%, 20%, 98%
Test method: HPLC
Packing: 25kg/drum, 100g/bag(For 98%)
Storage: Store in cool and dry place and keep away from strong direct light and heat
Shelf Life: Two years when properly stored
What is Securinine?
Securinine is an alkaloid isolated from Securinega suffruticosa. It was originally discovered over 50 years ago and reported to have potent biological activity. it has been used clinically in several other countries particularly China and Russia. In China it is considered one of the 50 fundamental Chinese herbs and is used in Chinese herbal medicine. Securinine has been found to be active as a γ-amino butyric acid (GABA) receptor antagonist. Its activity as a GABA antagonist, likely explains its reported clinical success in limited studies for the treatment of neurological conditions such as amyotrophic lateral sclerosis (ALS), poliomyelitis and multiple sclerosis.
Health Benefits of Securinine
Securinine is used in the treatment of contusions and nervous paralysis. Securinine acts as a stimulant on the central nervous system - it is particularly useful in the treatment of facial paralysis and is also thought to be of value in the treatment of multiple sclerosis.
Securinine may have potential utility against certain types of colon cancer. l-Securinine has an anti-tumor effect against colon cancer SW480 cell. The l-securinine can induce striking autophagy in SW480 cell in vitro. The autophagy induced by l-securinine is related with upregulating the expression of autophagy gene Beclin-1.
Securinine has also been reported to induce macrophage activation and therefore proposed as a potential therapeutic for infectious processes.
Montana State University researchers have discovered that securinine can be used as an adjuvant to promote innate immunity. The researchers have shown securinine functions with new modes of action that potentially eliminate problems of traditional approaches to enhancing innate immunity. In vivo and in vitro studies have demonstrated securinine triggers innate resistance to bacterial infections. Unlike approaches such as using Toll-like Receptors (TLRs) that may stimulate.