Common name: Oleanolic acid
Synonyms: Oleanic acid, Caryophyllin, Astrantiagenin C, Giganteumgenin C, Virgaureagenin B
CAS NO.: 508-02-1
Molecular Formula: C30H48O3
Molecular Weight: 456.711
Structure:

Specification: 80%, 85%, 98%( off white to white Powder)
Test method: HPLC
Product Main Quality Items：

Specification	98%
Appearance	white Powder
Contents(Calculated on dry basis by HPLC)	NLT98%
Water contents	NMT2%

Packing: 1kg/bag, 10kg/bag, 25kg/drum
Storage: Store in cool and dry place and keep away from strong direct light and heat
Shelf Life: Two years when properly stored
Please see the typical HPLC of 98% Oleanolic acid as follow:

Applications and Health Benefits:

What is Oleanolic acid?

Oleanolic acid is a naturally occurring pentacyclic triterpenoid related to betulinic acid. It is widely distributed in food and plants where it exists as a free acid or as an aglycone of triterpenoid saponins.
In China, oleanolic acid has been used as an over the counter (OTC) hepatoprotective drug for decades. Oleanolic acid and its derivatives present a wide variety of biological activities, supporting their pharmaceutical uses for multiple diseases.

Health Benefits of Oleanolic acid:

1. Hepatoprotection benefits

Oleanolic acid and ursolic acid are well known for their hepatoprotective effects for both acute chemically induced liver injury and chronic liver fibrosis and cirrhosis. They are still used alone or in combination with other hepatoprotective ingredients as oral medications. The beneficial effects of these triterpenoids on the liver could be due to their anti-oxidant and anti-inflammatory actions, and their effects on drug-metabolizing enzymes. These triterpenoids are effective inducers of metallothionein, a small cysteinerich protein acting like glutathione in the body’s defense against toxic insults. Induction of metallothionein could be an important mechanism for the generalized beneficial effects of these triterpenoids, but not the sole mechanism in protection against chemically induced liver injury.

2. Anti-Diabetic Activity

Diabetes is a complex and progressive disease which results from impaired insulin secretion and/or sensitivity. It is associated with different metabolic complications which affect body organs such as the eyes, kidney, blood arteries and the nerves. Oleanolic acid has been used as therapeutic agent in models of diabetes to improve insulin action, inhibit gluconeogenesis and promote glucose utilization. OA lacks the adipogenic activity unlike the commonly used antidiabetic therapeutics such as insulin or thiazolidinediones that up-regulate glucose transport in periphery and often lead to weight gain. Thus OA can prove to be quite a promising and better therapeutic modality without the adipogenic activity observed with other anti-diabetic or anti-obesity therapeutic agents.
The association between insulin resistance and type 2 diabetes has long been recognized and established. Insulin resistance is the hallmark of type 2 diabetes and a major predictor of its onset. In insulin resistant HepG2 cells, treatment with 25 µmol/L of OA improved insulin sensitivity by increasing the expression of insulin receptor substrate 1 (IRS-1) and glucose transporter.

3. Anti-Tumour/Anti-Cancer Effects of Oleanolic Acid and Its Derivatives

A number of studies have reported the anti-tumour and anti-cancer activities of oleanolic acid against tumour and cancer growth in different in vitro and in vivo models. For example, OA inhibits the growth of transplanted tumour in mice and proliferation of liver hepatocellular cells (HepG2).
It was suggested that the anti-tumour activity of OA is through the upregulation of the tumour protein, cyclooxygenase-2 (COX-2) mediated activation of mitochondrial apoptotic pathway and cell cycle arrest. On the other hand, there was an induction of cell death by treatment with a combination of second mitochondrial-derived activator of caspases (SMAC) mimetic BV6 and OA in human hepatocellular cells.

4. Antioxidant Activity

Oxidative stress is known to be involved in the pathogenesis of various chronic diseases and hence antioxidant therapy is a promising strategy for the management and treatment of these diseases.
The reports of biological activities of OA have been sometimes attributed to its antioxidant effect. For example, oleanolic acid from Ligustrum lucidum was shown to decrease the malonaldehyde (MDA) level and increase superoxide dismutase (SOD) and gluthatione peroxidase (GSH-px) activities in alloxan induced-diabetic rats. The level of MDA (by product of lipid peroxidation), the activities of SOD and GPX (key antioxidant enzymes) are important determinants of antioxidant status in mammalian tissues. Similarly, in an in vitro study, OA increased the production of glutathione and the expression of key antioxidant enzymes.

5. Anti-Inflammatory Potential

Inflammation plays a key role in the development and progression of various diseases such as insulin resistance and diabetes, cancer and asthma. In human umbilical vein endothelial cells (HUVECs), OA has been shown to have anti-inflammatory properties by inhibiting the release of liposaccharide (LPS) mediated high mobility group box 1 (HMGB1) and cell adhesion molecules (CAMs) expression. HMGBI is a protein that up-regulates pro-inflammatory cytokines in several inflammatory diseases. Similarly, Lee et al. reported that OA mitigated LPS-induced pro-inflammatory responses by the down-regulation of the expression of nuclear factor-κB (NF-κB) and tumor necrosis factor-α (TNF-α) (biomarkers of inflammation) in vivo and in vitro studies.