Common name: Diindolylmethane
Synonyms: 3,3'-Diindolylmethane, diindolylmethane, di(1H-indol-3-yl)methane
Active ingredients: Diindolylmethane
CAS NO.: 1968-05-4
Molecular Formula: C17H14N2
Molecular Weight: 246.31
Main Specifications: 98%
Test method: HPLC
Appearance: Off-white to white powder
Heavy Metals: NMT10ppm
Residual solvent: Conform to USP39, EP8.0
Packing: 25KG/ cardboard drum
Storage: Store in cool and dry place and keep away from strong direct light and heat
Shelf Life: Two years when properly stored
Diindolylmethane is a constituent of cruciferous vegetables such as cabbage and broccoli It has many benefits to support overall health. Diindolylmethane is also made in the body from a chemical called indole-3-carbinol, which is found in cruciferous vegetables such as cauliflower and broccoli. Diindolylmethane might act like estrogen in the body, but might also block estrogen effects. It appears to help destroy cancer cells and reduce swelling.
Health Benefits of Diindolylmethane
1. Cancer Prevention
Test-tube and animal studies suggest that DIM supplements may help prevent the growth and spread of breast cancer cells.
A yearlong study gave 130 women with breast cancer on tamoxifen therapy either a placebo or 150 mg of DIM twice a day. DIM supplements resulted in a significantly improved ratio of two types of estrogen — 2-hydroxyestrone and 16-hydrozyestrone.
Although research is ongoing, increasing the ratio of 2-hydrozyestrone to 16-hydrozyesterone may reduce breast cancer risk and cause anti-tumor effects.
A 30-day study in 19 post-menopausal women with early-stage breast cancer found that taking 108 mg of DIM per day also resulted in beneficial changes in estrogen levels.
Test-tube and animal studies indicate that DIM protects against ovarian, prostate, and colon cancers as well. All the same, human studies are needed.
Notably, a mouse study found that DIM helped prevent cervical cancer. However, in a 6-month study in 551 women with cervical abnormalities, taking 150 mg of DIM per day had no effect on cervical cell changes.
2. Boost weight loss
Given that estrogen plays an important role in regulating fat accumulation, DIM supplements may aid weight loss — although no human research currently supports this effect.
All the same, studies link an imbalance of estrogen — either too much or too little — to an increased risk of weight gain in both men and women.
Furthermore, DIM supplements may stimulate fat breakdown and inhibit fat cell formation.
In one study in mice on a high fat diet, 23 mg of DIM per pound (50 mg per kg) of body weight significantly reduced the formation of new fat cells.
3. Fight hormonal acne
DIM supplements are sometimes used to treat hormonal acne. Hormonal acne is a symptom of hormonal imbalance. DIM helps rebalance your hormones as well as decrease sebum production, which can significantly reduce acne flare-ups. Best results happen when you combine DIM with dietary and lifestyle changes.