Common name: Citicoline
Synonyms: cytidine 5'-diphosphocholine, CDP-choline, Citicholine
Active ingredients: Citicoline
CAS NO.: 987-78-0
Molecular Formula: C14H26N4O11P2
Molecular Weight: 488.32
Main Specifications: 98%
Test method: HPLC
Appearance: White powder
Heavy Metals: NMT10ppm
Residual solvent: Conform to USP39, EP8.0
Packing: 1, 5, 10, 20KG/ aluminum bags or fiber drums
Storage: Store in cool and dry place and keep away from strong direct light and heat
Shelf Life: Two years when properly stored
Citicoline is a nutrient that is particularly important for brain health and healthy cognition. Or, rather, it is a precursor to both acetylcholine and phosphatidylcholine, both of which are vital compounds for the brain.
Acetylcholine is a neurotransmitter. Neurotransmitters are signaling molecules that aid and enable basic cognitive functions. Phosphatidylcholine, meanwhile, is a phospholipid. This means that it is a fatty acid containing molecule. It is key for maintaining cell membrane health.
Benefits of Citicoline
1. Cognitive Enhancement.
Cognition tends to decline with aging, due to reduced brain blood flow or other causes. A review of 14 clinical trials concluded that CDP-choline could improve memory and behavior in people with mild to moderate cognitive impairment, including those with poor brain circulation.
According to the data from over 2,800 older patients, memory problems disappeared in 21% and improved in 45% of the cases upon receiving citicoline. This study lacked a placebo control so we should take the results with a grain of salt.
In two clinical trials on 135 healthy adults, citicoline (250-500 mg) improved focus and mental clarity.
A beverage with caffeine and CDP-choline (250 mg) enhanced cognition and reduced reaction times in 60 volunteers. Caffeine is a known stimulant and it likely contributed to the results.
2. Enhance Stroke Recovery.
Cut blood supply to a specific brain region can kill the neurons and inflict massive brain damage. Citicoline may help by strengthening nerve membranes and blocking free radical production.
According to a meta-analysis of 4 clinical trials (1,300+ patients), citicoline at 2,000 mg within the first 24 h after a stroke increases the chance of complete recovery by 38%.
The data from over 4,000 stroke survivors reveal that citicoline improves the outcomes and aids in recovery; higher doses (2,000 – 4,000 mg) were more effective. The lack of placebo control in this study doesn’t allow for definite conclusions.
3. Improve vision Problems.
Just like it shields the nerves in the brain and spinal cord, citicoline may have the same beneficial effects on the optic nerve. It may reverse the damage of neurons in your retina and help with eye disorders such as: Glaucoma, Amblyopia, Optic neuropathy.
Increased eye pressure and other factors can damage the optic nerve and cause glaucoma, sometimes even leading to total blindness.
In two clinical trials with 80 glaucoma patients, long-term treatment with oral citicoline repaired nerve damage, improved eyesight, and slowed down disease progression.
Eye drops with citicoline showed the same results in another two clinical trials (68 patients).
Amblyopia or “lazy eye” occurs when the eye and brain don’t communicate well. It results in blurry vision in one eye.
Oral citicoline improved standard lazy eye treatment (eye patching) in three clinical trials with 190 children.
Injections with CDP-choline (1,000 mg daily) healed the optic nerve and improved vision in 10 adults with amblyopia. This study had a tiny sample and lacked a placebo control, making the results questionable.
Optic neuropathy is another form of optic nerve damage that may hinder your eyesight. In 26 patients with optic neuropathy, citicoline (1,600 mg/day for 2 months) sharpened vision by repairing nerve damage.