Common name: Apigenin
CAS NO.: 520-36-5
Molecular Formula: C15-H10-O5
Molecular Weight: 270.24
Specification: 90%, 98%
Test method: HPLC
Packing: 5KG/ package
Storage: Store in cool and dry place and keep away from strong direct light and heat
Shelf Life: Two years when properly stored
What is Apigenin?
Apigenin is a Bioflavonoids compound (specifically a flavone) which is found in a wide variety of plants and herbs. It is very abundant in chamomile tea, and exerts Anxiety-reducing effects when consumed in these high doses. At even higher doses, it may be sedative.
Health Benefits of Apigenin
In case of injury or disease, microglia are recruited to the site of the pathology and become activated as evidenced by morphological changes and expression of pro-inflammatory cytokines. Evidence suggests that microglia proliferate by cell division to create gliosis at the site of pathological conditions such as the amyloid plaques in Alzheimer's disease and the substantia nigra of Parkinson's disease patients. The hyperactivation of microglia contributes to neurotoxicity. In the present study we tested the hypothesis that anti-inflammatory compounds modulate the progression of cell cycle and induce apoptosis of the activated cells.
Antidepressant-like effects of apigenin and 2,4,5-trimethoxycinnamic acid from Perilla frutescens plant in the forced swimming test.
Biol Pharm Bull. 2003.
Apigenin inhibits VEGF and HIF-1 expression via PI3K/AKT/p70S6K1 and HDM2/p53 pathways.
Apigenin is a nontoxic dietary flavonoid that has been shown to possess anti-tumor properties and therefore poses special interest for the development of a novel chemopreventive and/or chemotherapeutic agent for cancer. Investigations of the mechanisms of the cancer-preventive activity of apigenin (4',5,7,-trihydroxyflavone), a plant-derived, anti-carcinogenic flavonoid, showed its interference with cell proliferation, survival, and gap junctional coupling.